GENE THERAPY MAURO GIACCA PDF

Mauro Giacca International Centre for Genetic Engineering and Biotechnology Since , external Professor in the course Gene Therapy at the Medical. Gene Therapy has 3 ratings and 0 reviews. I entered the gene therapy field in the mids, being fascinated by the immense potential of genes as drugs. Find Gene Therapy by Giacca, Mauro at Biblio. Uncommonly good collectible and rare books from uncommonly good booksellers.

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Research Interests and Description Group Members. His current research interest focuses on the development of novel biotherapeutics for cardiovascular disorders, with special emphasis on the identification of growth factors and microRNAs able to induce new blood vessel formation and cardiac regeneration gens patients with myocardial infarction or heart failure.

He is gsne expert in the use of adeno-associated virus AAV vectors for cardiovascular applications and also maintains a strong interest in the molecular biology of HIV-1 infection. He has published over papers in peer-reviewed international journals and numerous reviews or chapters in published books and university text books.

He is the author of the book “Gene Therapy”, Springer ed. He regularly presents his research activity at meetings and invited seminars worldwide. He also regularly contributes articles to national newspapers and popular science magazines. Giacca M on PubMed. Reversible Notch1 acetylation tunes proliferative signalling in cardiomyocytes.

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Cardiovasc Res Circ Res Intracoronary Cytoprotective Gene Therapy: J Am Coll Cardiol 66, AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia. Nat Commun 6, Nuclear architecture dictates HIV-1 integration site selection. Harnessing the microRNA pathway for cardiac mauri.

J Mol Cell Cardiol 89, Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system. Extra- and intracellular factors regulating cardiomyocyte proliferation in giaccs life.

Epigenetic modification at Notch responsive promoters blunts efficacy of inducing Notch pathway reactivation after myocardial viacca. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell 15, Cell Host Microbe 13, Functional screening identifies miRNAs inducing cardiac regeneration.

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Nature Med 16, Nature Struct Mol Biol 16, Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice. J Clin Invest Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol Therqpy marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated maueo the newly formed vessels.

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Mol Cell 19, Transcellular protein transduction using hterapy Tat protein of HIV Adv Drug Deliv Rev 57, Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Fine mapping of a replication origin of human DNA. Scientific Activity His current research interest focuses on the development of novel biotherapeutics for cardiovascular disorders, with special emphasis on the identification of growth factors and microRNAs able to induce new blood vessel formation and cardiac regeneration in patients with myocardial infarction or heart failure.

Cardiovasc ResLesizza, P. Circ ResJohansen, A.

Circ ResEschenhagen, T. EBioMedicine, in press Carroll, K. Nat Commun 6, Marini, B. Circ ResZacchigna, S.

Cardiovasc ResPuente, B. CellFelician, G. Circ ResAguirre, A. Cell Stem Cell 15, Lusic, M. Cell Host Microbe 13, Eulalio, A. Nature kauro, Manganaro, L. Nature Med 16, Paolinelli, R. J Clin InvestCollesi, C. J Cell BiolFischer, C.

Research Groups

CellZentilin, L. BloodTodorovic, V. Mol Cell 19, Fittipaldi, A. ScienceMarzio, G. USA 95, Giacca, M.