Erythema elevatum diutinum (EED) is a rare, chronic dermatosis that is characterized by red–violet to red–brown papules, plaques, and. Erythema elevatum diutinum (EED) is a chronic form of leukocytoclastic vasculitis consisting of violaceous, red-brown, or yellowish papules. Erythema elevatum diutinum. Authoritative facts about the skin from DermNet New Zealand.

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The pathogenesis of EED is not eritdma clear; however, the prevailing and traditional theories are based on immune complex deposition within vessel walls, complement fixation, inflammation, and subsequent vascular destruction.

Dapsone, a sulfonamide antibiotic that impairs erritema chemotaxis and function, is the most effective treatment agent, but relapse is common upon discontinuation. These patients are middle aged women, with multiple pruritic lesions of several months’duration.

Erythema elevatum diutinum presenting with a giant annular pattern.

A rare case report. Search Advanced search allows to you precisely focus your query. J Am Acad Dermatol. Support Center Support Center. None Diutiinum of first submission: Pathophysiology Although the etiology of EED is unknown, circulating immune complexes, with repeated deposition, associated inflammation, and partial healing are thought to represent the underlying pathogenesis.

Views Read Edit View history. Erythema elevatum diutinum EED is a chronic leukocytoclastic vasculitis LCV that was initially described by Hutchinson in and subsequently by Bury in They typically are symmetrically distributed and favor acral and periarticular sites, specifically the extensor surfaces of the elbows, knees, ankles, hands, and fingers.


Diktinum removed from hand. The fibrosis of late lesions is most likely a result of chronic dermal injury of leukocytoclastic vasculitis. A year old male Caucasian patient, born and residing in Campinas, had a history of hyperchromic macules, bilaterally located in the medial and lateral malleolar zone of the ankles and on the heels and dorsal aspect of the feet. Previous treatment with topical corticosteroids had been unsuccessful.

Localized chronic fibrosing vasculitis: Clinically is characterized by red, purple, brown or yelow papules, plaques or nodules. Erythema elevatum diutinum EED is a chronic and rare dermatosis that is considered to be a variant of leukocytoclastic vasculitis.

Eritema elevatum diutinum | Actas Dermo-Sifiliográficas

The cause of EED is not yet defined, but it has been associated with the following conditions:. Lesions often are asymptomatic, though patients may experience pain or a burning sensation. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content.

The patient was no longer using dapsone and dermatological examination showed only residual lesions. However, in some cases after evolving over a year period it may spontaneously clear.

Epidemiology EED is rare, with descriptions of only several hundred cases in the literature. Jessica Newburger ; George J. The majority of cases resolve spontaneously over a period of 5 to 10 years, but the disease can last up to 40 years.


Consequently, even eriteja the association of EED with HIV infection is infrequent, laboratory investigation for this virus should be requested in conventional cases, and especially in cases of atypical and exacerbated clinical manifestations. Regardless of treatment, the recurrence rate of EED is high if the underlying triggering factors are not controlled.

Histologically, early lesions diuhinum erythema elevatum diutinum show leukocytoclastic vasculitis. One month after diagnosing HIV infection, the patient presented a neurological condition of right-side motor impairment.

Erythema elevatum diutinum

Niacinamide, an in vitro specific inhibitor of cyclic AMP, acts as a transfer factor needed for the suppression of antigen-induced lymphocyte transformation.

Erythema elevatum diutinum in association with IgA monoclonal gammopathy: PMC ] [ PubMed: Eritemw essential telangiectasia Hereditary hemorrhagic telangiectasia Unilateral nevoid telangiectasia.

An earlier onset occurs more often in the setting of HIV infection. It is probably mediated by immune complexes.

Paroxysmal hand hematoma Postcardiotomy syndrome Deep vein thrombosis Superficial thrombophlebitis Mondor’s disease Blueberry muffin baby Fibrinolysis syndrome. J Eur Acad Dermatol Venereol.